ORFanBase
ORFanBase is a comprehensive database of orphan genes and taxonomically restricted genes (TRGs) for investigators to explore the properties of these exceptional coding sequences in a comparative fashion, not limited to a handful of study groups, but globally across all domains of life and even viruses.
Sequences with limited taxonomic distribution which are also functionally essential to their species, represent a pattern wholly unexplored. We hope that through ORFanBase researchers would be able to find a rigorous analytical mathematical model for essential genes and proteins, so that we can estimate their probability of changing under known evolutionary processes.
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